A friend within the heart: natriuretic peptide receptor signaling
نویسندگان
چکیده
منابع مشابه
A friend within the heart: natriuretic peptide receptor signaling.
leading cause of death throughout the industrialized nations of the world. Central to this statistic is our current inability to effectively repair or otherwise reverse severe forms of cardiac dysfunction and pathologic remodeling that characterizes a failing heart. In response to hypertension, ischemic disease, valvular insufficiency, viral myocarditis, and genetic mutations in sacomeric prote...
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The natriuretic peptides are considered to be cardioprotective; however, their receptors have not been identified in human myocardium using radiolabeled analogs. Dendroaspis natriuretic peptide (DNP) has been recently identified as a new member of this peptide family and is thought to be less susceptible to enzymatic degradation. Therefore, we have developed the novel radiolabeled analog [125I]...
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IRCCS Neuromed, Pozzilli, Italy; William Harvey Heart Centre, Barts & The London School of Medicine & Dentistry, London, UK; Cardiovascular Center OLV Hospital, Aalst, Belgium; Dept. of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome, Italy; Dept. of Pharmacological and Biomolecular Sciences, University of Milan; and Dept...
متن کاملNatriuretic peptide receptors and the heart.
It is 20 years since de Bold reported that homogenates of normal atria stimulated a natriuresis and diuresis when administered intravenously to rats. This observation led to the isolation of atrial natriuretic peptide (ANP) from cardiac tissue. Subsequently other peptides with a similar ring structure and biological properties have been recognised, named in alphabetical order—BNP, CNP, and DNP—...
متن کاملA splice variant of the guanylyl cyclase-A receptor interferes with atrial natriuretic peptide (ANP) signaling
Background Activation of the homodimeric transmembrane guanylyl cyclase-A (GC-A) receptor upon binding of its extracellular ligands, atrial (ANP) and B-type (BNP) natriuretic peptides, leads to cyclic GMP formation in many types of cells. This NP/GC-A pathway has a critical role in the endocrine regulation of arterial blood pressure and volume and in the local counter-regulation of cardiac hype...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2003
ISSN: 0021-9738
DOI: 10.1172/jci200318389